5/4/2025
Last update
5/4/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.5
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
We explored the effectiveness of omega-3 fatty acid (PUFA) supplements in improving heart failure. Through a comprehensive network meta-analysis, we examined data from 14 randomized controlled trials involving over 9,000 participants.
Our findings showed that taking high doses of omega-3s (2000-4000 mg daily) for a year or more led to significant improvements in heart function, specifically in left ventricular ejection fraction and peak oxygen consumption. However, lower doses or shorter use didn’t yield these benefits, and there were no notable increases in dropout rates or overall mortality.
This suggests that while omega-3s can be beneficial for heart function in heart failure patients, careful consideration of the dosage and duration is essential.
Our findings showed that taking high doses of omega-3s (2000-4000 mg daily) for a year or more led to significant improvements in heart function, specifically in left ventricular ejection fraction and peak oxygen consumption. However, lower doses or shorter use didn’t yield these benefits, and there were no notable increases in dropout rates or overall mortality.
This suggests that while omega-3s can be beneficial for heart function in heart failure patients, careful consideration of the dosage and duration is essential.
Read More
9
We explored the potential of docosahexaenoic acid (DHA) in protecting against ischemic stroke in diabetic mice. The study found that administering DHA led to reduced stroke damage, including smaller brain infarcts and less brain swelling.
Interestingly, DHA appeared to lower inflammation by decreasing neutrophils in the brain and lessening apoptosis, which is cell death. Additionally, there were notable changes in gene expression, promoting anti-inflammatory and neuroprotective pathways.
Overall, DHA shows promise as a therapeutic option for managing strokes in diabetic patients.
Interestingly, DHA appeared to lower inflammation by decreasing neutrophils in the brain and lessening apoptosis, which is cell death. Additionally, there were notable changes in gene expression, promoting anti-inflammatory and neuroprotective pathways.
Overall, DHA shows promise as a therapeutic option for managing strokes in diabetic patients.
Read More
9
We explored how omega-3 polyunsaturated fatty acids (PUFAs) relate to coronary heart disease (CHD) risk through a thorough review of 36 studies. By looking at different types of omega-3 PUFAs, we found that higher levels correlate with a reduced risk of CHD. Specifically, both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) showed beneficial effects. In fact, CHD patients had noticeably lower omega-3 levels compared to healthy individuals, emphasizing the potential importance of these fatty acids in heart health.
Read More
Most Useful Reviews
9
Good price
21 people found this helpful
Great product at a good price! The capsules are large but easy to swallow, and the dosage is rich. Recommended for cardiovascular health, taken by the whole family for three months with a break.
Read More
9
Better cardiovascular
6 people found this helpful
I've taken omega as recommended, resulting in improved skin, better metabolism, and enhanced cardiovascular support. I feel great and highly recommend it!
Read More
9
Improved brain function
2 people found this helpful
A lifesaver for a tired brain! I grew up without eating fish, leading to poor memory and brain function. Now, I've realised that to enhance brain usage, I need to nourish it. Omega-3 is crucial, and I've found that taking DHA-500 alongside fish oil yielded impressive results. After a month, my memory improved, and my thought processes became quicker. Additionally, I've noticed healthier hair and skin. At 25, I intend to continue this without interruptions, as my body’s processes are starting to slow down.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.5
- All Researches
9
We examined how different fatty acid types, specifically acylcarnitines, affect heart health. Our study compared saturated and monounsaturated acylcarnitines with omega-3 derived types, like EPA and DHA. We found that saturated and monounsaturated types can harm heart function, significantly reducing cardiac contractility and cell viability. In contrast, the omega-3 acylcarnitines EPAC and DHAC did not impair heart functionality or cell viability. This suggests that omega-3s may offer a safer option for heart health compared to other fatty acids, particularly in those with specific health conditions.
Read More
9
We explored the effectiveness of omega-3 fatty acid (PUFA) supplements in improving heart failure. Through a comprehensive network meta-analysis, we examined data from 14 randomized controlled trials involving over 9,000 participants.
Our findings showed that taking high doses of omega-3s (2000-4000 mg daily) for a year or more led to significant improvements in heart function, specifically in left ventricular ejection fraction and peak oxygen consumption. However, lower doses or shorter use didn’t yield these benefits, and there were no notable increases in dropout rates or overall mortality.
This suggests that while omega-3s can be beneficial for heart function in heart failure patients, careful consideration of the dosage and duration is essential.
Our findings showed that taking high doses of omega-3s (2000-4000 mg daily) for a year or more led to significant improvements in heart function, specifically in left ventricular ejection fraction and peak oxygen consumption. However, lower doses or shorter use didn’t yield these benefits, and there were no notable increases in dropout rates or overall mortality.
This suggests that while omega-3s can be beneficial for heart function in heart failure patients, careful consideration of the dosage and duration is essential.
Read More
9
We explored the potential of docosahexaenoic acid (DHA) in protecting against ischemic stroke in diabetic mice. The study found that administering DHA led to reduced stroke damage, including smaller brain infarcts and less brain swelling.
Interestingly, DHA appeared to lower inflammation by decreasing neutrophils in the brain and lessening apoptosis, which is cell death. Additionally, there were notable changes in gene expression, promoting anti-inflammatory and neuroprotective pathways.
Overall, DHA shows promise as a therapeutic option for managing strokes in diabetic patients.
Interestingly, DHA appeared to lower inflammation by decreasing neutrophils in the brain and lessening apoptosis, which is cell death. Additionally, there were notable changes in gene expression, promoting anti-inflammatory and neuroprotective pathways.
Overall, DHA shows promise as a therapeutic option for managing strokes in diabetic patients.
Read More
9
We explored how omega-3 polyunsaturated fatty acids (PUFAs) relate to coronary heart disease (CHD) risk through a thorough review of 36 studies. By looking at different types of omega-3 PUFAs, we found that higher levels correlate with a reduced risk of CHD. Specifically, both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) showed beneficial effects. In fact, CHD patients had noticeably lower omega-3 levels compared to healthy individuals, emphasizing the potential importance of these fatty acids in heart health.
Read More
9
We explored how dihydroartemisinin (DHA) can protect the heart from damage caused by doxorubicin, a common cancer treatment. Through a series of tests on mice and heart cells, we found that DHA not only helped reduce heart dysfunction but also lessened oxidative stress and oxidative cell death.
The study demonstrated that DHA works by activating important cellular pathways and promoting the cleaning out of damaged cell parts. This means DHA could be a valuable option for mitigating the harmful effects of doxorubicin on the heart.
The study demonstrated that DHA works by activating important cellular pathways and promoting the cleaning out of damaged cell parts. This means DHA could be a valuable option for mitigating the harmful effects of doxorubicin on the heart.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Good price
21 people found this helpful
Great product at a good price! The capsules are large but easy to swallow, and the dosage is rich. Recommended for cardiovascular health, taken by the whole family for three months with a break.
Read More
9
Better cardiovascular
6 people found this helpful
I've taken omega as recommended, resulting in improved skin, better metabolism, and enhanced cardiovascular support. I feel great and highly recommend it!
Read More
9
Improved brain function
2 people found this helpful
A lifesaver for a tired brain! I grew up without eating fish, leading to poor memory and brain function. Now, I've realised that to enhance brain usage, I need to nourish it. Omega-3 is crucial, and I've found that taking DHA-500 alongside fish oil yielded impressive results. After a month, my memory improved, and my thought processes became quicker. Additionally, I've noticed healthier hair and skin. At 25, I intend to continue this without interruptions, as my body’s processes are starting to slow down.
Read More
9
Enhances cardiovascular function
1 people found this helpful
I’ve always taken fish oil for cardiovascular health. The high DHA content is ideal for passing through blood vessel barriers to nourish the brain. This reputable brand offers many benefits and is suitable for all ages. I recommend it to everyone.
Read More
9
Reduced cholesterol levels
1 people found this helpful
This was one of the first supplements I ordered from Ayherb. I paired it with sunflower lecithin for high cholesterol. The results surpassed my expectations! The high concentrations of DHA and EPA effectively protect my cardiovascular system and lower "bad" cholesterol. The capsules are easy to swallow with no unpleasant odours. This brand is recognised for its quality.
Read More
Frequently Asked Questions
9
Improved brain function
2 people found this helpful
A lifesaver for a tired brain! I grew up without eating fish, leading to poor memory and brain function. Now, I've realised that to enhance brain usage, I need to nourish it. Omega-3 is crucial, and I've found that taking DHA-500 alongside fish oil yielded impressive results. After a month, my memory improved, and my thought processes became quicker. Additionally, I've noticed healthier hair and skin. At 25, I intend to continue this without interruptions, as my body’s processes are starting to slow down.
9
Better cardiovascular
6 people found this helpful
I've taken omega as recommended, resulting in improved skin, better metabolism, and enhanced cardiovascular support. I feel great and highly recommend it!
8
Supports memory care
1 people found this helpful
In the elderly, low DHA levels can increase the risk of memory loss. Supplementing with DHA is prudent for brain health, aiding development and reducing chronic condition symptoms. It may help prevent dementia and relieve stress. A daily intake of 500–1,700 mg may improve cognitive function.
9
Reduced cholesterol levels
1 people found this helpful
This was one of the first supplements I ordered from Ayherb. I paired it with sunflower lecithin for high cholesterol. The results surpassed my expectations! The high concentrations of DHA and EPA effectively protect my cardiovascular system and lower "bad" cholesterol. The capsules are easy to swallow with no unpleasant odours. This brand is recognised for its quality.
7.5
Energy source
8 people found this helpful
This Omega-3 acid has an excellent ratio of components. It offers good cardiovascular support and is an irreplaceable energy source. I take it in the morning with vitamin D.
7.5
Cardiovascular support
This is the best omega I've tried! It's great for supporting the cardiovascular system and managing cholesterol.
9
We explored the effectiveness of omega-3 fatty acid (PUFA) supplements in improving heart failure. Through a comprehensive network meta-analysis, we examined data from 14 randomized controlled trials involving over 9,000 participants.
Our findings showed that taking high doses of omega-3s (2000-4000 mg daily) for a year or more led to significant improvements in heart function, specifically in left ventricular ejection fraction and peak oxygen consumption. However, lower doses or shorter use didn’t yield these benefits, and there were no notable increases in dropout rates or overall mortality.
This suggests that while omega-3s can be beneficial for heart function in heart failure patients, careful consideration of the dosage and duration is essential.
Our findings showed that taking high doses of omega-3s (2000-4000 mg daily) for a year or more led to significant improvements in heart function, specifically in left ventricular ejection fraction and peak oxygen consumption. However, lower doses or shorter use didn’t yield these benefits, and there were no notable increases in dropout rates or overall mortality.
This suggests that while omega-3s can be beneficial for heart function in heart failure patients, careful consideration of the dosage and duration is essential.
9
We explored how omega-3 polyunsaturated fatty acids (PUFAs) relate to coronary heart disease (CHD) risk through a thorough review of 36 studies. By looking at different types of omega-3 PUFAs, we found that higher levels correlate with a reduced risk of CHD. Specifically, both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) showed beneficial effects. In fact, CHD patients had noticeably lower omega-3 levels compared to healthy individuals, emphasizing the potential importance of these fatty acids in heart health.
8
Fatty acids influence cardiovascular risk
We explored the connection between fatty acids (FAs) and cardiovascular disease (CVD) using data from nearly 173,000 participants. Our examination revealed that higher levels of saturated FAs were linked to greater cardiovascular risks, especially for even-chain types.
Importantly, we found that docosahexaenoic acid (DHA) and other long-chain n-3 polyunsaturated FAs were associated with a reduced risk of coronary heart disease. Although some results suggested inconsistencies, overall, DHA seems beneficial for heart health, warranting further research to confirm these findings.
Importantly, we found that docosahexaenoic acid (DHA) and other long-chain n-3 polyunsaturated FAs were associated with a reduced risk of coronary heart disease. Although some results suggested inconsistencies, overall, DHA seems beneficial for heart health, warranting further research to confirm these findings.
7
We examined the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on the risk of atrial fibrillation (AF), a common heart rhythm disorder.
Through a thorough review of various studies—including randomized clinical trials and cohort studies—we focused on how DHA influences cardiovascular health. Interestingly, our findings revealed a complex relationship between omega-3 intake and AF risk.
While higher dietary consumption of omega-3 was linked to a decreased risk of AF, we found that pharmaceutical doses of omega-3 fats could actually increase this risk in a dose-dependent manner. The trials indicated a significant increase in AF risk associated with higher doses of DHA and eicosapentaenoic acid (EPA), suggesting that moderation is key.
This dual effect may be related to changes in vagal tone, where moderate levels promote heart health, while excessive amounts may trigger issues. Ultimately, we observed that maintaining a balanced intake of omega-3s is crucial for cardiovascular wellbeing.
Through a thorough review of various studies—including randomized clinical trials and cohort studies—we focused on how DHA influences cardiovascular health. Interestingly, our findings revealed a complex relationship between omega-3 intake and AF risk.
While higher dietary consumption of omega-3 was linked to a decreased risk of AF, we found that pharmaceutical doses of omega-3 fats could actually increase this risk in a dose-dependent manner. The trials indicated a significant increase in AF risk associated with higher doses of DHA and eicosapentaenoic acid (EPA), suggesting that moderation is key.
This dual effect may be related to changes in vagal tone, where moderate levels promote heart health, while excessive amounts may trigger issues. Ultimately, we observed that maintaining a balanced intake of omega-3s is crucial for cardiovascular wellbeing.
References
- Liepinsh E, Gukalova B, Krims-Davis K, Kuka J, Leduskrasta A, et al. EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines. Biofactors. 2025;51:e70014. 10.1002/biof.70014
- Medoro A, Graziano F, Cardinale G, Voccola S, Zotti T, et al. The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation. Lipids Health Dis. 2025;24:102. 10.1186/s12944-025-02513-w
- Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. 10.1016/j.advnut.2025.100366
- Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. 10.1039/d4fo04961f
- Liu C, Guo J, Guan L, Li C, Hu X, et al. Docosahexaenoic acid protects against ischemic stroke in diabetic mice by inhibiting inflammatory responses and apoptosis. Exp Neurol. 2025;385:115075. 10.1016/j.expneurol.2024.115075
- Hegde PS, Agni MB, Rai P, Upadhyay SS, Aravind A, et al. Supplementation of diet with Astaxanthin and DHA prevents gestational and lactational undernourishment-induced metabolic derangements in dams: a metabolomic approach. J Dev Orig Health Dis. 2024;15:e30. 10.1017/S2040174424000345
- Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. 10.1017/S0007114524002708
- Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. 10.1093/eurjpc/zwae315
- Zhang P, Munier JJ, Wiese CB, Vergnes L, Link JC, et al. X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction. Nat Commun. 2024;15:5571. 10.1038/s41467-024-49764-2
- Xiao Y, Chen Y, Pietzner A, Elbelt U, Fan Z, et al. Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies. Nutrients. 2024;16. 10.3390/nu16111610
- Dinu M, Sofi F, Lotti S, Colombini B, Mattioli AV, et al. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis. Eur J Prev Cardiol. 2024;31:1863. 10.1093/eurjpc/zwae184
- Lin ZH, Xiang HQ, Yu YW, Xue YJ, Wu C, et al. Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy. FASEB J. 2024;38:e23677. 10.1096/fj.202400222RR
- Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.028
- Liboriussen C, Nygaard L, Jensen JD, Schmidt EB, Glerup RI, et al. Low Plasma Marine N-3 Polyunsaturated Fatty Acids are Associated with Increased Risk of Cardiovascular Events in Patients Treated with Maintenance Hemodialysis. J Ren Nutr. 2025. 10.1053/j.jrn.2025.02.001
- Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. 10.3390/jcdd12020060
- Ren Y, Chen B, Zhang H, Xu S. A cohort study reveals shared and distinct serum metabolic biomarkers for major adverse cardiovascular events in middle-aged and older adults. Geroscience. 2025. 10.1007/s11357-025-01544-6
- Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. 10.3390/jcm14010026
- Arghavani H, Bilodeau JF, Rudkowska I. Association Between Circulating Fatty Acids and Blood Pressure: A Review. Curr Nutr Rep. 2025;14:15. 10.1007/s13668-024-00602-3
- Lamon-Fava S. Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation. Prostaglandins Other Lipid Mediat. 2025;176:106948. 10.1016/j.prostaglandins.2025.106948
- Berkowitz L, Echeverría G, Salazar C, Faúndez C, Coe CL, et al. Lipidomic Signature of Healthy Diet Adherence and Its Association with Cardiometabolic Risk in American Adults. Nutrients. 2024;16. 10.3390/nu16233995
- O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. 10.1016/j.pcad.2024.11.003
- So J, Yao JH, Magadmi R, Matthan NR, Lamon-Fava S. Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2024;203:102655. 10.1016/j.plefa.2024.102655
- Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. 10.3389/fnut.2024.1423228
- Koutsaliaris IK, Pantazi D, Tsouka AN, Argyropoulou O, Tellis CC, et al. Differential Effect of Omega-3 Fatty Acids on Platelet Inhibition by Antiplatelet Drugs In Vitro. Int J Mol Sci. 2024;25. 10.3390/ijms251810136
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
- Patil T, Gregory M, Savona N, Jarmukli N, Leonard CE. Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints. Clin Drug Investig. 2025;45:69. 10.1007/s40261-024-01417-4
- Fukuda T, Nakajima T, Hasegawa T, Amano H, Arikawa T, et al. Relationship Between Serum ω-3 Polyunsaturated Fatty Acid Concentration and Fatty Acid Fraction of Epicardial Adipose Tissue in Patients With Cardiovascular Disease. Cureus. 2024;16:e73417. 10.7759/cureus.73417
- Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. 10.3390/nu16213614
- Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. 10.1038/s44319-024-00271-x
- Follonier C, Rabassa G, Branca M, Carballo D, Koskinas K, et al. Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes. Atheroscler Plus. 2024;58:1. 10.1016/j.athplu.2024.09.002
